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Activated because of the antibiotic rifampicin and a variety of plant metabolites, for example hyperforin, guggulipid, colupulone, and isoflavones. Reaction to unique ligands is species-unique. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a reaction aspect in the promoters on the CYP3A4 and ABCB1/MDR1 g